5FPQ
Structure of Homo sapiens acetylcholinesterase phosphonylated by sarin.
Summary for 5FPQ
Entry DOI | 10.2210/pdb5fpq/pdb |
Related | 5FOQ 5FPP |
Descriptor | ACETYLCHOLINESTERASE, PENTAETHYLENE GLYCOL (3 entities in total) |
Functional Keywords | hydrolase, signaling protein, acetylcholinesterase, sarin, hi-6, qm, density functional theory calculations, michaelis complex. |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell junction, synapse . Isoform T: Nucleus. Isoform H: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side : P22303 |
Total number of polymer chains | 2 |
Total formula weight | 119372.66 |
Authors | Allgardsson, A.,Berg, L.,Akfur, C.,Hornberg, A.,Worek, F.,Linusson, A.,Ekstrom, F. (deposition date: 2015-12-02, release date: 2016-05-11, Last modification date: 2024-01-10) |
Primary citation | Allgardsson, A.,Berg, L.,Akfur, C.,Hornberg, A.,Worek, F.,Linusson, A.,Ekstrom, F.J. Structure of a Prereaction Complex between the Nerve Agent Sarin, its Biological Target Acetylcholinesterase, and the Antidote Hi-6. Proc.Natl.Acad.Sci.USA, 113:5514-, 2016 Cited by PubMed: 27140636DOI: 10.1073/PNAS.1523362113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report