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5FNC

Dynamic Undocking and the Quasi-Bound State as tools for Drug Design

Summary for 5FNC
Entry DOI10.2210/pdb5fnc/pdb
Related5FND 5FNF
DescriptorHEAT SHOCK PROTEIN, HSP90-ALPHA, 6-CHLORO-4-N-[(4-METHYLPHENYL)METHYL]PYRIMIDINE- 2,4-DIAMINE, SULFATE ION, ... (4 entities in total)
Functional Keywordshsp90, drug design, chaperone, oncology
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight27138.67
Authors
Ruiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.M.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X. (deposition date: 2015-11-13, release date: 2016-11-23, Last modification date: 2024-01-10)
Primary citationRuiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X.
Dynamic undocking and the quasi-bound state as tools for drug discovery.
Nat Chem, 9:201-206, 2017
Cited by
PubMed: 28221352
DOI: 10.1038/nchem.2660
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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