5FI3

HETEROYOHIMBINE SYNTHASE THAS1 FROM CATHARANTHUS ROSEUS - COMPLEX WITH NADP+

Summary for 5FI3

Entry DOI	10.2210/pdb5fi3/pdb
Descriptor	Tetrahydroalstonine synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION, ... (5 entities in total)
Functional Keywords	heteroyohimbine synthase, medium chain dehydrogenase/reductase, nadp+ dependent enzyme, zinc binding site, oxidoreductase
Biological source	Catharanthus roseus (Madagascar periwinkle)
Total number of polymer chains	2
Total formula weight	78636.54
Authors	Stavrinides, A.,Tatsis, E.C.,Caputi, L.,Foureau, E.,Stevenson, C.E.M.,Lawson, D.M.,Courdavault, V.,O'Connor, S.E. (deposition date: 2015-12-22, release date: 2016-07-27, Last modification date: 2017-08-30)
Primary citation	Stavrinides, A.,Tatsis, E.C.,Caputi, L.,Foureau, E.,Stevenson, C.E.,Lawson, D.M.,Courdavault, V.,O'Connor, S.E. Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nat Commun, 7:12116-12116, 2016 Cited by PubMed: 27418042 DOI: 10.1038/ncomms12116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation