5F9E
Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one
Summary for 5F9E
Entry DOI | 10.2210/pdb5f9e/pdb |
Descriptor | Protein kinase C theta type, 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one (3 entities in total) |
Functional Keywords | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q04759 |
Total number of polymer chains | 2 |
Total formula weight | 84709.20 |
Authors | |
Primary citation | Katoh, T.,Takai, T.,Yukawa, T.,Tsukamoto, T.,Watanabe, E.,Mototani, H.,Arita, T.,Hayashi, H.,Nakagawa, H.,Klein, M.G.,Zou, H.,Sang, B.C.,Snell, G.,Nakada, Y. Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC theta inhibitors. Bioorg.Med.Chem., 24:2466-2475, 2016 Cited by PubMed: 27117263DOI: 10.1016/j.bmc.2016.04.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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