5F19

The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2

Summary for 5F19

• Entry DOI: 10.2210/pdb5f19/pdb
• Related: 5F1A
• Descriptor: Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: membrane protein, cyclooxygenase, cyxlooxygenase-2, monotopic, aspirin, complex, covalent inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 132205.01

Authors

Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (deposition date: 2015-11-30, release date: 2016-03-16, Last modification date: 2023-09-27)

• Primary citation: Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G.; Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.; Biochemistry, 55:1226-1238, 2016; PubMed: 26859324; DOI: 10.1021/acs.biochem.5b01378

Experimental method

X-RAY DIFFRACTION (2.04 Å)