5ETW
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
Summary for 5ETW
Entry DOI | 10.2210/pdb5etw/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (1~{R})-1-cyclohexyl-2-pyrido[3,4-b]indol-9-yl-ethanol, ... (4 entities in total) |
Functional Keywords | ido1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P14902 |
Total number of polymer chains | 2 |
Total formula weight | 92590.18 |
Authors | Wu, S.Y.,Peng, Y.H.,Wu, J.S. (deposition date: 2015-11-18, release date: 2016-02-10, Last modification date: 2023-11-08) |
Primary citation | Peng, Y.H.,Ueng, S.H.,Tseng, C.T.,Hung, M.S.,Song, J.S.,Wu, J.S.,Liao, F.Y.,Fan, Y.S.,Wu, M.H.,Hsiao, W.C.,Hsueh, C.C.,Lin, S.Y.,Cheng, C.Y.,Tu, C.H.,Lee, L.C.,Cheng, M.F.,Shia, K.S.,Shih, C.,Wu, S.Y. Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. J.Med.Chem., 59:282-293, 2016 Cited by PubMed: 26642377DOI: 10.1021/acs.jmedchem.5b01390 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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