5ETH
RORy in complex with inverse agonist 3.
Summary for 5ETH
Entry DOI | 10.2210/pdb5eth/pdb |
Descriptor | Nuclear receptor ROR-gamma, 1-methyl-~{N}-(1-thiophen-2-ylcarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)-~{N}-[2,2,2-tris(fluoranyl)ethyl]indole-4-sulfonamide (3 entities in total) |
Functional Keywords | ror gamma, inverse agonist, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 2 |
Total formula weight | 53091.40 |
Authors | Marcotte, D.M. (deposition date: 2015-11-17, release date: 2016-04-27, Last modification date: 2023-09-27) |
Primary citation | Enyedy, I.J.,Powell, N.A.,Caravella, J.,van Vloten, K.,Chao, J.,Banerjee, D.,Marcotte, D.,Silvian, L.,McKenzie, A.,Hong, V.S.,Fontenot, J.D. Discovery of biaryls as ROR gamma inverse agonists by using structure-based design. Bioorg.Med.Chem.Lett., 26:2459-2463, 2016 Cited by PubMed: 27080181DOI: 10.1016/j.bmcl.2016.03.109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.803 Å) |
Structure validation
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