5ETH

RORy in complex with inverse agonist 3.

Summary for 5ETH

• Entry DOI: 10.2210/pdb5eth/pdb
• Descriptor: Nuclear receptor ROR-gamma, 1-methyl-~{N}-(1-thiophen-2-ylcarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)-~{N}-[2,2,2-tris(fluoranyl)ethyl]indole-4-sulfonamide (3 entities in total)
• Functional Keywords: ror gamma, inverse agonist, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P51449
• Total number of polymer chains: 2
• Total formula weight: 53091.40

Authors

Marcotte, D.M. (deposition date: 2015-11-17, release date: 2016-04-27, Last modification date: 2023-09-27)

• Primary citation: Enyedy, I.J.,Powell, N.A.,Caravella, J.,van Vloten, K.,Chao, J.,Banerjee, D.,Marcotte, D.,Silvian, L.,McKenzie, A.,Hong, V.S.,Fontenot, J.D.; Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.; Bioorg.Med.Chem.Lett., 26:2459-2463, 2016; PubMed: 27080181; DOI: 10.1016/j.bmcl.2016.03.109

Experimental method

X-RAY DIFFRACTION (2.803 Å)