5ELZ
Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog
Summary for 5ELZ
Entry DOI | 10.2210/pdb5elz/pdb |
Related | 4M7X 4M7Y |
Descriptor | Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pantothenate kinase, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm : Q8NVG0 |
Total number of polymer chains | 1 |
Total formula weight | 30839.69 |
Authors | Mottaghi, K.,Hughes, S.J.,Tempel, W.,Hong, B.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2015-11-05, release date: 2016-08-10, Last modification date: 2023-09-27) |
Primary citation | Hughes, S.J.,Barnard, L.,Mottaghi, K.,Tempel, W.,Antoshchenko, T.,Hong, B.S.,Allali-Hassani, A.,Smil, D.,Vedadi, M.,Strauss, E.,Park, H.W. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Acs Infect Dis., 2:627-641, 2016 Cited by PubMed: 27759386DOI: 10.1021/acsinfecdis.6b00090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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