5EK2
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
Summary for 5EK2
Entry DOI | 10.2210/pdb5ek2/pdb |
Related | 5EK3 5EK4 |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanone, ... (4 entities in total) |
Functional Keywords | inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 92598.11 |
Authors | Peng, Y.H.,Wu, J.S.,Wu, S.Y. (deposition date: 2015-11-03, release date: 2015-12-23, Last modification date: 2023-11-08) |
Primary citation | Peng, Y.H.,Ueng, S.H.,Tseng, C.T.,Hung, M.S.,Song, J.S.,Wu, J.S.,Liao, F.Y.,Fan, Y.S.,Wu, M.H.,Hsiao, W.C.,Hsueh, C.C.,Lin, S.Y.,Cheng, C.Y.,Tu, C.H.,Lee, L.C.,Cheng, M.F.,Shia, K.S.,Shih, C.,Wu, S.Y. Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1 J.Med.Chem., 59:282-293, 2016 Cited by PubMed: 26642377DOI: 10.1021/acs.jmedchem.5b01390 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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