5EG4

BOVINE TRYPSIN IN COMPLEX WITH CYCLIC INHIBITOR

Summary for 5EG4

• Entry DOI: 10.2210/pdb5eg4/pdb
• Related: 4MTB
• Descriptor: Cationic trypsin, CALCIUM ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: metal-binding, digestion, hydrolase-hydrolase inhibitor complex, hydrolase
• Biological source: Bos taurus (Bovine)
• Cellular location: Secreted, extracellular space: P00760
• Total number of polymer chains: 1
• Total formula weight: 24348.49

Authors

Knoerlein, A.,Wagner, S.,Heine, A.,Steinmetzer, T.,Klebe, G. (deposition date: 2015-10-26, release date: 2016-07-13, Last modification date: 2024-01-10)

• Primary citation: Hinkes, S.,Wuttke, A.,Saupe, S.M.,Ivanova, T.,Wagner, S.,Knorlein, A.,Heine, A.,Klebe, G.,Steinmetzer, T.; Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.; J.Med.Chem., 59:6370-6386, 2016; PubMed: 27280436; DOI: 10.1021/acs.jmedchem.6b00606

Experimental method

X-RAY DIFFRACTION (1.32 Å)