5ED6

crystal structure of human Hint1 H114A mutant complexing with ATP

Summary for 5ED6

Entry DOI	10.2210/pdb5ed6/pdb
Related	5ECB 5ECZ 5ED3 5ED5 5EDE 5EFL 5EFP
Descriptor	Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase, nucleotide binding, regulation of transcription, signal transduction
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28499.72
Authors	Wang, J.,Fang, P.,Guo, M. (deposition date: 2015-10-20, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Yu, J.,Liu, Z.,Liang, Y.,Luo, F.,Zhang, J.,Tian, C.,Motzik, A.,Zheng, M.,Kang, J.,Zhong, G.,Liu, C.,Fang, P.,Guo, M.,Razin, E.,Wang, J. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10:4664-4664, 2019 Cited by PubMed: 31604935 DOI: 10.1038/s41467-019-12710-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation