5ED2
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Summary for 5ED2
Entry DOI | 10.2210/pdb5ed2/pdb |
Related | 5ED1 |
Descriptor | Double-stranded RNA-specific editase 1, RNA (5'-R(P*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3'), RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ... (5 entities in total) |
Functional Keywords | deaminase, human, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 120961.47 |
Authors | Matthews, M.M.,Fisher, A.J. (deposition date: 2015-10-20, release date: 2016-04-13, Last modification date: 2023-09-27) |
Primary citation | Matthews, M.M.,Thomas, J.M.,Zheng, Y.,Tran, K.,Phelps, K.J.,Scott, A.I.,Havel, J.,Fisher, A.J.,Beal, P.A. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat.Struct.Mol.Biol., 23:426-433, 2016 Cited by PubMed: 27065196DOI: 10.1038/nsmb.3203 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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