5EAM
Crystal structure of human WDR5 in complex with compound 9o
Summary for 5EAM
Entry DOI | 10.2210/pdb5eam/pdb |
Related | 5EAL 5EAP 5EAR |
Descriptor | WD repeat-containing protein 5, ~{N}-[5-(1~{H}-indol-5-yl)-2-(4-methylpiperazin-1-yl)phenyl]-3-methyl-benzamide, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | wdr5, compound 9o, structural genomics, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P61964 |
Total number of polymer chains | 2 |
Total formula weight | 70044.49 |
Authors | DONG, A.,DOMBROVSKI, L.,SMIL, D.,GETLIK, M.,BOLSHAN, Y.,WALKER, J.R.,SENISTERRA, G.,PODA, G.,AL-AWAR, R.,SCHAPIRA, M.,VEDADI, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (deposition date: 2015-10-16, release date: 2015-11-04, Last modification date: 2023-09-27) |
Primary citation | Getlik, M.,Smil, D.,Zepeda-Velazquez, C.,Bolshan, Y.,Poda, G.,Wu, H.,Dong, A.,Kuznetsova, E.,Marcellus, R.,Senisterra, G.,Dombrovski, L.,Hajian, T.,Kiyota, T.,Schapira, M.,Arrowsmith, C.H.,Brown, P.J.,Vedadi, M.,Al-Awar, R. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J. Med. Chem., 59:2478-2496, 2016 Cited by PubMed: 26958703DOI: 10.1021/acs.jmedchem.5b01630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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