5E8A
Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor
Summary for 5E8A
Entry DOI | 10.2210/pdb5e8a/pdb |
Related | 5E88 5E89 |
Descriptor | Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, ... (4 entities in total) |
Functional Keywords | carbohydrate-recognition, beta sandwich, carbohydrate binding protein, sugar binding protein, inhibitor, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P17931 |
Total number of polymer chains | 1 |
Total formula weight | 16442.19 |
Authors | Collins, P.M.,Blanchard, H. (deposition date: 2015-10-13, release date: 2016-08-24, Last modification date: 2023-09-27) |
Primary citation | Delaine, T.,Collins, P.,MacKinnon, A.,Sharma, G.,Stegmayr, J.,Rajput, V.K.,Mandal, S.,Cumpstey, I.,Larumbe, A.,Salameh, B.A.,Kahl-Knutsson, B.,van Hattum, H.,van Scherpenzeel, M.,Pieters, R.J.,Sethi, T.,Schambye, H.,Oredsson, S.,Leffler, H.,Blanchard, H.,Nilsson, U.J. Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17:1759-1770, 2016 Cited by PubMed: 27356186DOI: 10.1002/cbic.201600285 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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