5E7N
Crystal Structure of RPA70N in complex with VU0085636
Summary for 5E7N
Entry DOI | 10.2210/pdb5e7n/pdb |
Descriptor | Replication protein A 70 kDa DNA-binding subunit, 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid (3 entities in total) |
Functional Keywords | inhibitor, complex, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13987.07 |
Authors | Gilston, B.A.,Patrone, J.D.,Pelz, N.F.,Bates, B.S.,Souza-Fagundes, E.M.,Vangamudi, B.,Camper, D.,Kuznetsov, A.,Browning, C.F.,Feldkamp, M.D.,Olejniczak, E.T.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (deposition date: 2015-10-12, release date: 2016-01-27, Last modification date: 2023-09-27) |
Primary citation | Patrone, J.D.,Pelz, N.F.,Bates, B.S.,Souza-Fagundes, E.M.,Vangamudi, B.,Camper, D.V.,Kuznetsov, A.G.,Browning, C.F.,Feldkamp, M.D.,Frank, A.O.,Gilston, B.A.,Olejniczak, E.T.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W. Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A. Chemmedchem, 11:893-899, 2016 Cited by PubMed: 26748787DOI: 10.1002/cmdc.201500479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.21 Å) |
Structure validation
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