5E1G

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208

Summary for 5E1G

Entry DOI	10.2210/pdb5e1g/pdb
Related	5DZJ 5DZP 5E1I
Descriptor	L,D-transpeptidase 2, (2~{S},3~{R},4~{R})-4-(2-cyclohexyloxy-2-oxidanylidene-ethyl)sulfanyl-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid (3 entities in total)
Functional Keywords	peptidoglycan synthesis enzyme, cell wall enzyme, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Cell membrane ; Lipid-anchor : I6Y9J2
Total number of polymer chains	2
Total formula weight	79449.48
Authors	Kumar, P.,Lamichhane, G.,Ginell, S.L. (deposition date: 2015-09-29, release date: 2016-10-12, Last modification date: 2023-09-27)
Primary citation	Kumar, P.,Kaushik, A.,Lloyd, E.P.,Li, S.G.,Mattoo, R.,Ammerman, N.C.,Bell, D.T.,Perryman, A.L.,Zandi, T.A.,Ekins, S.,Ginell, S.L.,Townsend, C.A.,Freundlich, J.S.,Lamichhane, G. Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13:54-61, 2017 Cited by PubMed: 27820797 DOI: 10.1038/nchembio.2237 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.852 Å)

Structure validation