5E13

Crystal structure of Eosinophil-derived neurotoxin in complex with the triazole double-headed ribonucleoside 11c

Summary for 5E13

Entry DOI	10.2210/pdb5e13/pdb
Descriptor	Non-secretory ribonuclease, 3'-{4-[(4-amino-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}-3'-deoxyadenosine (3 entities in total)
Functional Keywords	hydrolase, nuclease
Biological source	Homo sapiens (Human)
Cellular location	Lysosome : P10153
Total number of polymer chains	1
Total formula weight	18846.64
Authors	Chatzileontiadou, D.S.M.,Stravodimos, G.A.,Kantsadi, A.L.,Leonidas, D.D. (deposition date: 2015-09-29, release date: 2015-11-18, Last modification date: 2024-01-10)
Primary citation	Chatzileontiadou, D.S.,Parmenopoulou, V.,Manta, S.,Kantsadi, A.L.,Kylindri, P.,Griniezaki, M.,Kontopoulou, F.,Telopoulou, A.,Prokova, H.,Panagopoulos, D.,Boix, E.,Balatsos, N.A.,Komiotis, D.,Leonidas, D.D. Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg.Chem., 63:152-165, 2015 Cited by PubMed: 26551065 DOI: 10.1016/j.bioorg.2015.10.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation