5DYW

Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide

Summary for 5DYW

• Entry DOI: 10.2210/pdb5dyw/pdb
• Descriptor: Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hydrolase, human butyrylcholinesterase ad alzheimer disease sulfonamide
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 128169.43

Authors

Coquelle, N.,Brus, B.,Colletier, J.P. (deposition date: 2015-09-25, release date: 2017-01-18, Last modification date: 2020-07-29)

• Primary citation: Kosak, U.,Brus, B.,Knez, D.,Sink, R.,Zakelj, S.,Trontelj, J.,Pislar, A.,Slenc, J.,Gobec, M.,Zivin, M.,Tratnjek, L.,Perse, M.,Saat, K.,Podkowa, A.,Filipek, B.,Nachon, F.,Brazzolotto, X.,Wieckowska, A.,Malawska, B.,Stojan, J.,Rascan, I.M.,Kos, J.,Coquelle, N.,Colletier, J.P.,Gobec, S.; Development of an in-vivo active reversible butyrylcholinesterase inhibitor.; Sci Rep, 6:39495-39495, 2016; PubMed: 28000737; DOI: 10.1038/srep39495

Experimental method

X-RAY DIFFRACTION (2.5 Å)