5DXE
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P4 and Estradiol
Summary for 5DXE
Entry DOI | 10.2210/pdb5dxe/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, ESTRADIOL, ... (4 entities in total) |
Functional Keywords | estrogen receptor alpha, stapled peptide, peptide mimetic, breast cancer, hormone, somatic mutation, hormone receptor-peptide complex, hormone receptor/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 63200.97 |
Authors | Fanning, S.W.,Speltz, T.E.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (deposition date: 2015-09-23, release date: 2016-08-03, Last modification date: 2023-11-15) |
Primary citation | Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew.Chem.Int.Ed.Engl., 55:4252-4255, 2016 Cited by PubMed: 26928945DOI: 10.1002/anie.201510557 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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