5DT0

Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122

Summary for 5DT0

• Entry DOI: 10.2210/pdb5dt0/pdb
• Descriptor: Aurora kinase A, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide (3 entities in total)
• Functional Keywords: aurora a kinase, mitotic kinase, ppi, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• Total number of polymer chains: 1
• Total formula weight: 32201.88

Authors

Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,McKenzie, G.J.,Huggins, D.J.,Stockwell, S.,Stokes, J.A.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,Venkitaraman, A.R. (deposition date: 2015-09-17, release date: 2016-07-20, Last modification date: 2024-01-10)

• Primary citation: Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,Huggins, D.J.,Stockwell, S.R.,Stokes, J.E.,Tan, Y.S.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R.; Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.; Sci Rep, 6:28528-28528, 2016; PubMed: 27339427; DOI: 10.1038/srep28528

Experimental method

X-RAY DIFFRACTION (2.15 Å)