5DSY

Crystal structure of constitutively active PARP-2

Summary for 5DSY

Entry DOI	10.2210/pdb5dsy/pdb
Descriptor	Poly [ADP-ribose] polymerase 2, 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide (3 entities in total)
Functional Keywords	adp-ribosyl transferase, parp, parp-2, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	128853.78
Authors	Riccio, A.A.,Pascal, J.M. (deposition date: 2015-09-17, release date: 2016-07-27, Last modification date: 2023-09-27)
Primary citation	Dawicki-McKenna, J.M.,Langelier, M.F.,DeNizio, J.E.,Riccio, A.A.,Cao, C.D.,Karch, K.R.,McCauley, M.,Steffen, J.D.,Black, B.E.,Pascal, J.M. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol.Cell, 60:755-768, 2015 Cited by PubMed: 26626480 DOI: 10.1016/j.molcel.2015.10.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation