5DS3

Crystal structure of constitutively active PARP-1

Summary for 5DS3

Entry DOI	10.2210/pdb5ds3/pdb
Descriptor	Poly [ADP-ribose] polymerase 1, PENTAETHYLENE GLYCOL, 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, ... (5 entities in total)
Functional Keywords	adp-ribosyl transferase, parp-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30868.14
Authors	Langelier, M.F.,Pascal, J.M. (deposition date: 2015-09-16, release date: 2016-07-27, Last modification date: 2023-09-27)
Primary citation	Dawicki-McKenna, J.M.,Langelier, M.F.,DeNizio, J.E.,Riccio, A.A.,Cao, C.D.,Karch, K.R.,McCauley, M.,Steffen, J.D.,Black, B.E.,Pascal, J.M. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol.Cell, 60:755-768, 2015 Cited by PubMed: 26626480 DOI: 10.1016/j.molcel.2015.10.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation