5DLZ
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-({1-[(3-methylphe methyl]piperidin-4-yl}methyl)butanamide
Summary for 5DLZ
Entry DOI | 10.2210/pdb5dlz/pdb |
Descriptor | Bromodomain-containing protein 4, N-{[1-(3-methylbenzyl)piperidin-4-yl]methyl}-4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]butanamide (3 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, brd4_bd1, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15560.98 |
Authors | Raux, B.,Rebuffet, E.,Betzi, S.,Morelli, X. (deposition date: 2015-09-07, release date: 2016-06-01, Last modification date: 2024-01-10) |
Primary citation | Milhas, S.,Raux, B.,Betzi, S.,Derviaux, C.,Roche, P.,Restouin, A.,Basse, M.J.,Rebuffet, E.,Lugari, A.,Badol, M.,Kashyap, R.,Lissitzky, J.C.,Eydoux, C.,Hamon, V.,Gourdel, M.E.,Combes, S.,Zimmermann, P.,Aurrand-Lions, M.,Roux, T.,Rogers, C.,Muller, S.,Knapp, S.,Trinquet, E.,Collette, Y.,Guillemot, J.C.,Morelli, X. Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. Acs Chem.Biol., 11:2140-2148, 2016 Cited by PubMed: 27219844DOI: 10.1021/acschembio.6b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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