5DFP
Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036
Summary for 5DFP
Entry DOI | 10.2210/pdb5dfp/pdb |
Related | 5DEW 5DEY |
Descriptor | Serine/threonine-protein kinase PAK 1, 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13153 |
Total number of polymer chains | 1 |
Total formula weight | 33963.43 |
Authors | |
Primary citation | Ndubaku, C.O.,Crawford, J.J.,Drobnick, J.,Aliagas, I.,Campbell, D.,Dong, P.,Dornan, L.M.,Duron, S.,Epler, J.,Gazzard, L.,Heise, C.E.,Hoeflich, K.P.,Jakubiak, D.,La, H.,Lee, W.,Lin, B.,Lyssikatos, J.P.,Maksimoska, J.,Marmorstein, R.,Murray, L.J.,O'Brien, T.,Oh, A.,Ramaswamy, S.,Wang, W.,Zhao, X.,Zhong, Y.,Blackwood, E.,Rudolph, J. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. Acs Med.Chem.Lett., 6:1241-1246, 2015 Cited by PubMed: 26713112DOI: 10.1021/acsmedchemlett.5b00398 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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