Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5DEY

Crystal structure of PAK1 in complex with an inhibitor compound G-5555

Summary for 5DEY
Entry DOI10.2210/pdb5dey/pdb
Related5DEW 5DFP
DescriptorSerine/threonine-protein kinase PAK 1, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q13153
Total number of polymer chains2
Total formula weight67558.45
Authors
Oh, A.,Tam, C.,Wang, W. (deposition date: 2015-08-26, release date: 2016-01-27, Last modification date: 2016-06-01)
Primary citationNdubaku, C.O.,Crawford, J.J.,Drobnick, J.,Aliagas, I.,Campbell, D.,Dong, P.,Dornan, L.M.,Duron, S.,Epler, J.,Gazzard, L.,Heise, C.E.,Hoeflich, K.P.,Jakubiak, D.,La, H.,Lee, W.,Lin, B.,Lyssikatos, J.P.,Maksimoska, J.,Marmorstein, R.,Murray, L.J.,O'Brien, T.,Oh, A.,Ramaswamy, S.,Wang, W.,Zhao, X.,Zhong, Y.,Blackwood, E.,Rudolph, J.
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Acs Med.Chem.Lett., 6:1241-1246, 2015
Cited by
PubMed: 26713112
DOI: 10.1021/acsmedchemlett.5b00398
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon