5DC6
Crystal structure of D176N-Y306F HDAC8 in complex with a tetrapeptide substrate
Summary for 5DC6
Entry DOI | 10.2210/pdb5dc6/pdb |
Related | 5DC5 5DC7 5DC8 |
Descriptor | Histone deacetylase 8, Fluor-de-Lys tetrapeptide assay substrate, ZINC ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase 8, arginase fold, deacetylase, enzyme-substrate complex, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 88589.27 |
Authors | Decroos, C.,Lee, M.S.,Christianson, D.W. (deposition date: 2015-08-23, release date: 2016-02-03, Last modification date: 2023-11-15) |
Primary citation | Gantt, S.M.,Decroos, C.,Lee, M.S.,Gullett, L.E.,Bowman, C.M.,Christianson, D.W.,Fierke, C.A. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55:820-832, 2016 Cited by PubMed: 26806311DOI: 10.1021/acs.biochem.5b01327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.553 Å) |
Structure validation
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