5DC8

Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate

Summary for 5DC8

• Entry DOI: 10.2210/pdb5dc8/pdb
• Related: 5DC5 5DC6 5DC7
• Descriptor: Histone deacetylase 8, Fluor-de-Lys tetrapeptide assay substrate, ZINC ION, ... (6 entities in total)
• Functional Keywords: histone deacetylase 8, arginase fold, deacetylase, enzyme-substrate complex, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 88443.21

Authors

Decroos, C.,Lee, M.S.,Christianson, D.W. (deposition date: 2015-08-23, release date: 2016-02-03, Last modification date: 2023-11-15)

• Primary citation: Gantt, S.M.,Decroos, C.,Lee, M.S.,Gullett, L.E.,Bowman, C.M.,Christianson, D.W.,Fierke, C.A.; General Base-General Acid Catalysis in Human Histone Deacetylase 8.; Biochemistry, 55:820-832, 2016; PubMed: 26806311; DOI: 10.1021/acs.biochem.5b01327

Experimental method

X-RAY DIFFRACTION (1.3 Å)