5DC0

CRYSTAL STRUCTURE OF MONOBODY GG3/ABL1 SH2 DOMAIN COMPLEX

Summary for 5DC0

• Entry DOI: 10.2210/pdb5dc0/pdb
• Related: 5DC4 5DC9
• Descriptor: Fibronectin, Tyrosine-protein kinase ABL1 (3 entities in total)
• Functional Keywords: engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, tyrosine-protein kinase, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 23437.98

Authors

Wojcik, J.B.,Grabe, G.,Koide, S. (deposition date: 2015-08-22, release date: 2016-03-02, Last modification date: 2024-03-06)

• Primary citation: Wojcik, J.,Lamontanara, A.J.,Grabe, G.,Koide, A.,Akin, L.,Gerig, B.,Hantschel, O.,Koide, S.; Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.; J.Biol.Chem., 291:8836-8847, 2016; PubMed: 26912659; DOI: 10.1074/jbc.M115.707901

Experimental method

X-RAY DIFFRACTION (2.23 Å)