5D41

EGFR kinase domain in complex with mutant selective allosteric inhibitor

Summary for 5D41

Entry DOI	10.2210/pdb5d41/pdb
Descriptor	Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	allosteric inhibitor, egfr, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	76859.60
Authors	Yun, C.-H.,Park, E.,Eck, M.J. (deposition date: 2015-08-07, release date: 2016-06-08, Last modification date: 2023-09-27)
Primary citation	Jia, Y.,Yun, C.H.,Park, E.,Ercan, D.,Manuia, M.,Juarez, J.,Xu, C.,Rhee, K.,Chen, T.,Zhang, H.,Palakurthi, S.,Jang, J.,Lelais, G.,DiDonato, M.,Bursulaya, B.,Michellys, P.Y.,Epple, R.,Marsilje, T.H.,McNeill, M.,Lu, W.,Harris, J.,Bender, S.,Wong, K.K.,Janne, P.A.,Eck, M.J. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534:129-132, 2016 Cited by PubMed: 27251290 DOI: 10.1038/nature17960 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation