5D24
First bromodomain of BRD4 bound to inhibitor XD26
Summary for 5D24
Entry DOI | 10.2210/pdb5d24/pdb |
Descriptor | Bromodomain-containing protein 4, 4-acetyl-N-[3-(2-amino-2-oxoethoxy)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | gene regulation, inhibitor, bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15603.95 |
Authors | Wohlwend, D.,Huegle, M.,Gerhardt, S. (deposition date: 2015-08-05, release date: 2016-01-20, Last modification date: 2024-05-01) |
Primary citation | Hugle, M.,Lucas, X.,Weitzel, G.,Ostrovskyi, D.,Breit, B.,Gerhardt, S.,Einsle, O.,Gunther, S.,Wohlwend, D. 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59:1518-1530, 2016 Cited by PubMed: 26731611DOI: 10.1021/acs.jmedchem.5b01267 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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