5CYQ

HIV-1 reverse transcriptase complexed with 4-bromopyrazole

Summary for 5CYQ

Entry DOI	10.2210/pdb5cyq/pdb
Related	5CW1 5CXR 5CYM
Descriptor	HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total)
Functional Keywords	4-bromopyrazole, phasing, influenza endonuclease, fragment screening, transferase
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains	2
Total formula weight	117620.78
Authors	Bauman, J.D.,Arnold, E. (deposition date: 2015-07-30, release date: 2015-12-30, Last modification date: 2023-09-27)
Primary citation	Bauman, J.D.,Harrison, J.J.,Arnold, E. Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. IUCrJ, 3:51-60, 2016 Cited by PubMed: 26870381 DOI: 10.1107/S2052252515021259 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.147 Å)

Structure validation