5CYN

JC Virus large T-antigen origin binding domain F258L mutant

Summary for 5CYN

Entry DOI	10.2210/pdb5cyn/pdb
Descriptor	Large T antigen, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	dna binding domain, origin binding domain, viral protein, dna binding protein
Biological source	JC polyomavirus (JCPyV)
Cellular location	Host nucleus : P03072
Total number of polymer chains	1
Total formula weight	15054.31
Authors	Meinke, G.,Bohm, A.,Bullock, P.A. (deposition date: 2015-07-30, release date: 2015-12-16, Last modification date: 2023-09-27)
Primary citation	Meinke, G.,Phelan, P.J.,Shin, J.,Gagnon, D.,Archambault, J.,Bohm, A.,Bullock, P.A. Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains. Plos Pathog., 12:e1005362-e1005362, 2016 Cited by PubMed: 26735515 DOI: 10.1371/journal.ppat.1005362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation