5CU4
Crystal structure of CK2alpha bound to CAM4066
Summary for 5CU4
Entry DOI | 10.2210/pdb5cu4/pdb |
Descriptor | Casein kinase II subunit alpha, ACETATE ION, N-[(2-chlorobiphenyl-4-yl)methyl]-beta-alanyl-N-(3-carboxyphenyl)-beta-alaninamide, ... (4 entities in total) |
Functional Keywords | ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P68400 |
Total number of polymer chains | 1 |
Total formula weight | 39688.48 |
Authors | Brear, P.,De Fusco, C.,Georgiou, K.H.,Spring, D.,Hyvonen, M. (deposition date: 2015-07-24, release date: 2016-07-27, Last modification date: 2024-01-10) |
Primary citation | Brear, P.,De Fusco, C.,Hadje Georgiou, K.,Francis-Newton, N.J.,Stubbs, C.J.,Sore, H.F.,Venkitaraman, A.R.,Abell, C.,Spring, D.R.,Hyvonen, M. Specific inhibition of CK2 alpha from an anchor outside the active site. Chem Sci, 7:6839-6845, 2016 Cited by PubMed: 28451126DOI: 10.1039/c6sc02335e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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