5CLU
THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE
Summary for 5CLU
Entry DOI | 10.2210/pdb5clu/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase ii, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29331.37 |
Authors | D'Ambrosio, K.,De Simone, G. (deposition date: 2015-07-16, release date: 2015-11-11, Last modification date: 2024-01-10) |
Primary citation | Langella, E.,D'Ambrosio, K.,D'Ascenzio, M.,Carradori, S.,Monti, S.M.,Supuran, C.T.,De Simone, G. A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases. Chemistry, 22:97-100, 2016 Cited by PubMed: 26507456DOI: 10.1002/chem.201503748 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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