5CJO
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
Summary for 5CJO
Entry DOI | 10.2210/pdb5cjo/pdb |
Descriptor | Insulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain, ... (6 entities in total) |
Functional Keywords | hydrolase, fab, elbow-engineer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 166314.66 |
Authors | liang, w.g.,bailey, L.,tang, w.j. (deposition date: 2015-07-14, release date: 2016-07-20, Last modification date: 2023-09-27) |
Primary citation | Bailey, L.J.,Sheehy, K.M.,Dominik, P.K.,Liang, W.G.,Rui, H.,Clark, M.,Jaskolowski, M.,Kim, Y.,Deneka, D.,Tang, W.J.,Kossiakoff, A.A. Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J. Mol. Biol., 2017 Cited by PubMed: 29273204DOI: 10.1016/j.jmb.2017.12.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.287 Å) |
Structure validation
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