5CI7

Structure of ULK1 bound to a selective inhibitor

Summary for 5CI7

Entry DOI	10.2210/pdb5ci7/pdb
Related	4WNO
Descriptor	Serine/threonine-protein kinase ULK1, N-[3-({4-[(3-aminopropyl)amino]-5-iodopyrimidin-2-yl}amino)phenyl]pyrrolidine-1-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	inhibitor, kinase, autophagy, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33077.88
Authors	Lazarus, M.B.,Shokat, K.M. (deposition date: 2015-07-11, release date: 2015-08-26, Last modification date: 2023-09-27)
Primary citation	Lazarus, M.B.,Shokat, K.M. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorg.Med.Chem., 23:5483-5488, 2015 Cited by PubMed: 26275681 DOI: 10.1016/j.bmc.2015.07.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation