5CGJ

Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.

Summary for 5CGJ

Entry DOI	10.2210/pdb5cgj/pdb
Descriptor	Kelch-like ECH-associated protein 1, SULFATE ION, (3S)-1-(4-{[(2,3,5,6-tetramethylphenyl)sulfonyl]amino}naphthalen-1-yl)pyrrolidine-3-carboxylic acid, ... (4 entities in total)
Functional Keywords	beta propeller, inhibitor, complex, protein binding
Biological source	Mus musculus (Mouse)
Cellular location	Cytoplasm : Q9Z2X8
Total number of polymer chains	1
Total formula weight	37865.19
Authors	Schimanski-Breves, S.,Loenze, P.,Engel, C.K. (deposition date: 2015-07-09, release date: 2015-10-21, Last modification date: 2015-12-02)
Primary citation	Winkel, A.F.,Engel, C.K.,Margerie, D.,Kannt, A.,Szillat, H.,Glombik, H.,Kallus, C.,Ruf, S.,Gussregen, S.,Riedel, J.,Herling, A.W.,von Knethen, A.,Weigert, A.,Brune, B.,Schmoll, D. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J.Biol.Chem., 290:28446-28455, 2015 Cited by PubMed: 26459563 DOI: 10.1074/jbc.M115.678136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.36 Å)

Structure validation