5CCB

Crystal structure of human m1A58 methyltransferase in a complex with tRNA3Lys and SAH

Summary for 5CCB

Entry DOI	10.2210/pdb5ccb/pdb
Descriptor	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA3Lys, ... (6 entities in total)
Functional Keywords	trna a58 modification, methyl transferase-trna complex, class i methyltransferase fold, s-adenosyl-l-methionine cofactor, transferase-rna complex, transferase/rna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	112503.98
Authors	Finer-Moore, J.,Czudnochowski, N.,O'Connell III, J.D.,Wang, A.L.,Stroud, R.M. (deposition date: 2015-07-01, release date: 2015-11-04, Last modification date: 2023-09-27)
Primary citation	Finer-Moore, J.,Czudnochowski, N.,O'Connell, J.D.,Wang, A.L.,Stroud, R.M. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J.Mol.Biol., 427:3862-3876, 2015 Cited by PubMed: 26470919 DOI: 10.1016/j.jmb.2015.10.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation