5CAL
EGFR kinase domain mutant "TMLR" with compound 24
Summary for 5CAL
Entry DOI | 10.2210/pdb5cal/pdb |
Descriptor | Epidermal growth factor receptor, 2,2-dimethyl-3-[(4-{[2-methyl-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amino}pyrimidin-2-yl)amino]propanamide (2 entities in total) |
Functional Keywords | protein kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37931.86 |
Authors | Eigenbrot, C.,Yu, C. (deposition date: 2015-06-29, release date: 2015-10-28, Last modification date: 2024-03-06) |
Primary citation | Heald, R.,Bowman, K.K.,Bryan, M.C.,Burdick, D.,Chan, B.,Chan, E.,Chen, Y.,Clausen, S.,Dominguez-Fernandez, B.,Eigenbrot, C.,Elliott, R.,Hanan, E.J.,Jackson, P.,Knight, J.,La, H.,Lainchbury, M.,Malek, S.,Mann, S.,Merchant, M.,Mortara, K.,Purkey, H.,Schaefer, G.,Schmidt, S.,Seward, E.,Sideris, S.,Shao, L.,Wang, S.,Yeap, K.,Yen, I.,Yu, C.,Heffron, T.P. Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study. J.Med.Chem., 58:8877-8895, 2015 Cited by PubMed: 26455919DOI: 10.1021/acs.jmedchem.5b01412 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report