5C27
Crystal structure of SYK in complex with compound 2
Summary for 5C27
Entry DOI | 10.2210/pdb5c27/pdb |
Related | 5C26 |
Descriptor | Tyrosine-protein kinase SYK, GLU-VAL-TYR-GLU-SER, 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-N-[4-(methylcarbamoyl)phenyl]benzamide, ... (5 entities in total) |
Functional Keywords | spleen tyrosine kinase, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 2 |
Total formula weight | 36281.20 |
Authors | |
Primary citation | Lovering, F.,Aevazelis, C.,Chang, J.,Dehnhardt, C.,Fitz, L.,Han, S.,Janz, K.,Lee, J.,Kaila, N.,McDonald, J.,Moore, W.,Moretto, A.,Papaioannou, N.,Richard, D.,Ryan, M.S.,Wan, Z.K.,Thorarensen, A. Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP). Chemmedchem, 11:217-233, 2016 Cited by PubMed: 26381330DOI: 10.1002/cmdc.201500333 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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