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5C27

Crystal structure of SYK in complex with compound 2

Summary for 5C27
Entry DOI10.2210/pdb5c27/pdb
Related5C26
DescriptorTyrosine-protein kinase SYK, GLU-VAL-TYR-GLU-SER, 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-N-[4-(methylcarbamoyl)phenyl]benzamide, ... (5 entities in total)
Functional Keywordsspleen tyrosine kinase, inhibitor, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane : P43405
Total number of polymer chains2
Total formula weight36281.20
Authors
Han, S.,Chang, J. (deposition date: 2015-06-15, release date: 2015-10-07, Last modification date: 2016-02-03)
Primary citationLovering, F.,Aevazelis, C.,Chang, J.,Dehnhardt, C.,Fitz, L.,Han, S.,Janz, K.,Lee, J.,Kaila, N.,McDonald, J.,Moore, W.,Moretto, A.,Papaioannou, N.,Richard, D.,Ryan, M.S.,Wan, Z.K.,Thorarensen, A.
Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Chemmedchem, 11:217-233, 2016
Cited by
PubMed: 26381330
DOI: 10.1002/cmdc.201500333
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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