5BZZ
Crystal structure of human phosphatase PTEN in its reduced state
Summary for 5BZZ
Entry DOI | 10.2210/pdb5bzz/pdb |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, L(+)-TARTARIC ACID (3 entities in total) |
Functional Keywords | phosphatase, c2 domain, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm. Isoform alpha: Secreted : P60484 |
Total number of polymer chains | 4 |
Total formula weight | 149831.57 |
Authors | Lee, C.-U.,Bier, D.,Hennig, S.,Grossmann, T.N. (deposition date: 2015-06-11, release date: 2015-10-07, Last modification date: 2024-01-10) |
Primary citation | Lee, C.U.,Hahne, G.,Hanske, J.,Bange, T.,Bier, D.,Rademacher, C.,Hennig, S.,Grossmann, T.N. Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54:13796-13800, 2015 Cited by PubMed: 26418532DOI: 10.1002/anie.201506338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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