5BZX

Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex

Summary for 5BZX

Entry DOI	10.2210/pdb5bzx/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, VANADATE ION, L(+)-TARTARIC ACID, ... (4 entities in total)
Functional Keywords	phosphatase, c2 domain, disulfide, oxidized, vanadate, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm. Isoform alpha: Secreted : P60484
Total number of polymer chains	4
Total formula weight	149911.36
Authors	Lee, C.-U.,Bier, D.,Hennig, S.,Grossmann, T.N. (deposition date: 2015-06-11, release date: 2015-10-07, Last modification date: 2024-01-10)
Primary citation	Lee, C.U.,Hahne, G.,Hanske, J.,Bange, T.,Bier, D.,Rademacher, C.,Hennig, S.,Grossmann, T.N. Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54:13796-13800, 2015 Cited by PubMed: 26418532 DOI: 10.1002/anie.201506338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation