5BX0

An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

Summary for 5BX0

Entry DOI	10.2210/pdb5bx0/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, ethyl 2H-indazole-5-carboxylate (2 entities in total)
Functional Keywords	fragment screening, microscale thermophoresis, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
Total number of polymer chains	1
Total formula weight	39107.08
Authors	Vallee, F.,Steier, V.,Rak, A. (deposition date: 2015-06-08, release date: 2015-12-23, Last modification date: 2024-01-10)
Primary citation	Linke, P.,Amaning, K.,Maschberger, M.,Vallee, F.,Steier, V.,Baaske, P.,Duhr, S.,Breitsprecher, D.,Rak, A. An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery. J Biomol Screen, 21:414-421, 2016 Cited by PubMed: 26637553 DOI: 10.1177/1087057115618347 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.93 Å)

Structure validation