5BRR
Michaelis complex of tPA-S195A:PAI-1
Summary for 5BRR
Entry DOI | 10.2210/pdb5brr/pdb |
Descriptor | Plasminogen activator inhibitor 1, Tissue-type plasminogen activator, GLYCEROL, ... (5 entities in total) |
Functional Keywords | tissue-type plasminogen activator catalytic domain, plasminogen activator inhibitor 1, structure-activity relationship, thrombolysis, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P05121 Secreted, extracellular space: P00750 |
Total number of polymer chains | 2 |
Total formula weight | 71424.42 |
Authors | Gong, L. (deposition date: 2015-06-01, release date: 2015-09-02, Last modification date: 2017-10-18) |
Primary citation | Gong, L.,Liu, M.,Zeng, T.,Shi, X.,Yuan, C.,Andreasen, P.A.,Huang, M. Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1 J.Biol.Chem., 290:25795-25804, 2015 Cited by PubMed: 26324706DOI: 10.1074/jbc.M115.677567 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.16 Å) |
Structure validation
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