5BOU

Yeast 20S proteasome in complex with a beta1 / beta2 specific non-peptidic sulfonamide Ligand

Summary for 5BOU

• Entry DOI: 10.2210/pdb5bou/pdb
• Related: 1RYP
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, non-covalent ligand, binding analysis, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae S288c (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 732295.20

Authors

Beck, P.,Groll, M. (deposition date: 2015-05-27, release date: 2015-08-19, Last modification date: 2024-01-10)

• Primary citation: Beck, P.,Reboud-Ravaux, M.,Groll, M.; Identification of a beta 1/ beta 2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening.; Angew.Chem.Int.Ed.Engl., 54:11275-11278, 2015; PubMed: 26242779; DOI: 10.1002/anie.201505054

Experimental method

X-RAY DIFFRACTION (2.6 Å)