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5B7V

Human FGFR1 kinase in complex with CH5183284

Replaces:  3WJ6
Summary for 5B7V
Entry DOI10.2210/pdb5b7v/pdb
DescriptorFibroblast growth factor receptor 1, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein kinase, atp-binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains2
Total formula weight71426.05
Authors
Fukami, T.A.,Lukacs, C.M.,Janson, C. (deposition date: 2016-06-09, release date: 2016-06-22, Last modification date: 2023-11-08)
Primary citationNakanishi, Y.,Akiyama, N.,Tsukaguchi, T.,Fujii, T.,Sakata, K.,Sase, H.,Isobe, T.,Morikami, K.,Shindoh, H.,Mio, T.,Ebiike, H.,Taka, N.,Aoki, Y.,Ishii, N.
The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
Mol.Cancer Ther., 13:2547-2558, 2014
Cited by
PubMed: 25169980
DOI: 10.1158/1535-7163.MCT-14-0248
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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