5AZV

Crystal structure of hPPARgamma ligand binding domain complexed with 17-oxoDHA

Summary for 5AZV

Entry DOI	10.2210/pdb5azv/pdb
Related	5AZT
Descriptor	Peroxisome proliferator-activated receptor gamma, (4~{Z},7~{Z},10~{Z},13~{Z},19~{Z})-17-oxidanylidenedocosa-4,7,10,13,19-pentaenoic acid (3 entities in total)
Functional Keywords	nuclear receptor, transcription regulation, ligand binding domain, zinc-finger, dna binding, transcription, obesity, nucleus, receptor, activator, oxidized fatty acid, transcription factor, agonist, dual agonist, covalent, ppre, nuclear, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	63588.02
Authors	Egawa, D.,Itoh, T.,Yamamoto, K. (deposition date: 2015-10-23, release date: 2016-07-06, Last modification date: 2020-02-26)
Primary citation	Egawa, D.,Itoh, T.,Akiyama, Y.,Saito, T.,Yamamoto, K. 17-OxoDHA Is a PPAR alpha/gamma Dual Covalent Modifier and Agonist Acs Chem.Biol., 2016 Cited by PubMed: 27337155 DOI: 10.1021/acschembio.6b00338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation