5AX9

Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex with compund 9

Summary for 5AX9

Entry DOI	10.2210/pdb5ax9/pdb
Descriptor	TRAF2 and NCK-interacting protein kinase, 4-methoxy-3-[2-[(3-methoxy-4-morpholin-4-yl-phenyl)amino]pyridin-4-yl]benzenecarbonitrile, SULFATE ION, ... (4 entities in total)
Functional Keywords	inhibitor, kinase, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	106670.53
Authors	Ohbayashi, N.,Kukimoto-Niino, M.,Yamada, T.,Shirouzu, M. (deposition date: 2015-07-21, release date: 2016-07-27, Last modification date: 2023-11-08)
Primary citation	Masuda, M.,Uno, Y.,Ohbayashi, N.,Ohata, H.,Mimata, A.,Kukimoto-Niino, M.,Moriyama, H.,Kashimoto, S.,Inoue, T.,Goto, N.,Okamoto, K.,Shirouzu, M.,Sawa, M.,Yamada, T. TNIK inhibition abrogates colorectal cancer stemness Nat Commun, 7:12586-12586, 2016 Cited by PubMed: 27562646 DOI: 10.1038/ncomms12586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation