5AR8
RIP2 Kinase Catalytic Domain (1 - 310) complex with Biphenylsulfonamide
Summary for 5AR8
Entry DOI | 10.2210/pdb5ar8/pdb |
Related | 5AR2 5AR3 5AR4 5AR5 5AR7 |
Descriptor | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, 2,6-bis(fluoranyl)-N-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide (3 entities in total) |
Functional Keywords | transferase, kinase domain, kinase inhibitor, structure-based drug design, inhibitor selectivity |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : O43353 |
Total number of polymer chains | 2 |
Total formula weight | 76581.47 |
Authors | Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. (deposition date: 2015-09-24, release date: 2015-10-21, Last modification date: 2024-01-10) |
Primary citation | Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Ouellette, M.,Totoritis, R.,Schwartz, B.,King, B.W.,Wisnoski, D.D.,Kang, J.,Eidam, P.M.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. Crystal Structures of Human Rip2 Kinase Catalytic Domain Complexed with ATP-Competitive Inhibitors: Foundations for Understanding Inhibitor Selectivity. Bioorg.Med.Chem., 23:7000-, 2015 Cited by PubMed: 26455654DOI: 10.1016/J.BMC.2015.09.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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